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Carbidopa allows patients treated for Parkinson’s disease to use much lower doses of levodopaSome patients who responded poorly to levodopa have improved on SINEMETThis is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous systemCarbidopa has not been shown to enhance the intrinsic efficacy of levodopa.
SINEMET may have similar effects on thinking and behaviorThis abnormal thinking and behavior may present with one or more symptomsincluding paranoid ideationdelusionshallucinationsconfusionpsychotic-like behaviordisorientationaggressive behavioragitationand delirium.
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