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TelmisartanMicardisand AmlodipineNorvascFactorial Design Study for the Treatment of Hypertension.
The precise mechanisms by which amlodipine relieves angina have not been fully delineatedbut are thought to include the following:
HemodynamicsFollowing administration of therapeutic doses to patients with hypertensionNorvasc produces vasodilation resulting in a reduction of supine and standing blood pressuresThese decreases in blood pressure are not accompanied by a significant change in heart rate or plasma catecholamine levels with chronic dosingAlthough the acute intravenous administration of amlodipine decreases arterial blood pressure and increases heart rate in hemodynamic studies of patients with chronic stable anginachronic oral administration of amlodipine in clinical trials did not lead to clinically significant changes in heart rate or blood pressures in normotensive patients with angina.
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