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Procardia dilates the main coronary arteries and coronary arteriolesboth in normal and ischemic regionsand is a potent inhibitor of coronary artery spasmwhether spontaneous or ergonovine-inducedThis property increases myocardial oxygen delivery in patients with coronary artery spasmand is responsible for the effectiveness of Procardia in vasospasticPrinzmetal’s or variantanginaWhether this effect plays any role in classical angina is not clearbut studies of exercise tolerance have not shown an increase in the maximum exercise rate-pressure producta widely accepted measure of oxygen utilizationThis suggests thatin generalrelief of spasm or dilation of coronary arteries is not an important factor in classical angina.
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