Treatment with paroxetine can be initiated .
Information about Paroxetine.
Swallow the extended-release and regular tablets wholedo not chew or crush them.
Do not start or stop taking paroxetine during pregnancy without your doctor’s advice.
Paxil CR12.5 mg PO qDay initiallymay increase by 12.5 mg qWeeknot to exceed 37.5 mg/day.
Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetineA dangerous drug interaction could occurMAO inhibitors include isocarboxazidlinezolidphenelzinerasagilineselegilineand tranylcypromineAfter you stop taking paroxetine you must wait at least 14 days before you start taking an MAO inhibitor.
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at steady state, when the cyp2d6 pathway is essentially saturated, paroxetine clearance is governed by alternative p 450 isozymes that, unlike cyp2d6, show no evidence of saturation see precautions tricyclic antidepressants tcas .