In summary, this study established that in type 2 diabetic patients acute administration of the lipase inhibitor, orlistat, had adverse effects on the glycaemic and blood pressure responses to a meal containing both fat and carbohydrate.
Information about Orlistat.
XENICAL is contraindicated during pregnancybecause weight loss offers no potential benefit to a pregnant woman and may result in fetal harmA minimum weight gainand no weight lossis currently recommended for all pregnant womenincluding those who are already overweight or obesedue to the obligatory weight gain that occurs in maternal tissues during pregnancyNo embryotoxicity or teratogenicity was seen in animals that received orlistat at doses much higher than the recommended human doseIf this drug is used during pregnancyor if the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard of maternal weight loss to the fetus.
Loss of virological control has been reported in HIV-infected patients taking orlistat concomitantly with antiretroviral drugs such as atazanavirritonavirtenofovir disoproxil fumarateemtricitabineand with the combinations lopinavir/ritonavir and emtricitabine/efavirenz/tenofovir disoproxil fumarateThe exact mechanism for this is unclearbut may include a drug-drug interaction that inhibits systemic absorption of the antiretroviral drugHIV RNA levels should be frequently monitored in patients who take XENICAL while being treated for HIV infectionIf there is a confirmed increase in HIV viral loadXENICAL should be discontinued.
Because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and betacarotenepatients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutritionsee WARNINGS AND PRECAUTIONSThe vitamin supplement should be taken at least 2 hours before or after the administration of XENICALsuch as at bedtime.
For patients receiving both XENICAL and levothyroxine therapyadminister levothyroxine and XENICAL at least 4 hours apartPatients treated concomitantly with XENICAL and levothyroxine should be monitored for changes in thyroid function.
Read the label of all food items you consumepaying special attention to the number of servings per containerYour doctornutrition counseloror dietitian can help you develop a healthy eating plan.
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