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The black box warning now clearly reads that promethazine hydrochloride injections should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depressionIt also advises caution should be exercised when administering the drug in the form of an injection to patients 2 and older.
Promethazine can cause side effects that may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be awake and alertAvoid drinking alcoholwhich can increase some of the side effects of promethazineThere are many other medicines that can interact with promethazineTell your doctor about all the prescription and over-the-counter medications you useThis includes vitaminsmineralsherbal productsand drugs prescribed by other doctorsDo not start using a new medication without telling your doctorKeep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
It is not known whether promethazine will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnant while using this medicine.
Promethazine hydrochloride tablets may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous taskssuch as driving a vehicle or operating machineryThe use of alcohol or other central-nervous-system depressants such as sedatives/hypnoticsincluding barbituratesnarcoticsnarcotic analgesicsgeneral anestheticstricyclic antidepressantsand tranquilizersmay enhance impairmentsee WARNINGS-CNS Depression and PRECAUTIONSDRUG INTERACTIONSPediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities.
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