Warning is also advised when midazolam is administered concomitantly with drugs that are known to discourage the p450 34a enzyme set, such as cimetidine tagamet , erythromycin, diltiazem cardizem , verapamil calan isoptin verelan , ketoconazole, and itraconazole sporanox .
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Electrical activity through the AV node dependsto a significant degreeupon calcium influx through the slow channelBy decreasing the influx of calciumISOPTIN prolongs the effective refractory period within the AV node and slows AV conduction in a rate related manner.
Verapamil HCI is an almost whitecrystalline powderpractically free of odorwith a bitter taste.
FlecainideA study of healthy volunteers showed that the concomitant administration of flecainide and verapamil may have additive effects on myocardial contractilityAV conductionand repolarizationConcomitant therapy with flecainide and verapamil may result in additive negative inotropic effect and prolongation of atrioventricular conduction.
Before taking verapamiltell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.
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