In approximately 10 of patients, significant amounts of orally ingested digoxin are metabolized in the gut by intestinal bacteria.
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Various studies are said to have caused uncertainty over the side effects of digoxinwith some suggesting it could increase mortality riskThe researchers therefore aimed to carry out a systematic review to pool the evidence on the safety of the drugparticularly looking at mortality effects.
Drug interactions may change how your medications work or increase your risk for serious side effectsThis document does not contain all possible drug interactionsKeep a list of all the products you useincluding prescription/nonprescription drugs and herbal productsand share it with your doctor and pharmacistDo not startstopor change the dosage of any medicines without your doctor’s approval.
Overallthe review found that people taking digoxin had a 21higher risk of death from any cause compared to people not taking the drug.
Monitor serum concentration closely when used for rate control in patients with atrial fibrillationserum concentration that are not properly conrolled are associated with increased risk of mortality.
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increased serum digoxin concentrations have been reported in patients who received digoxin and diclofenac sodium or ibuprofen.