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Literature suggests that concomitant use of PPIs with methotrexateprimarily at high dosesee methotrexate prescribing informationmay elevate and prolong serum levels of methotrexate and/or its metabolitepossibly leading to methotrexate toxicitiesIn high-dose methotrexate administration a temporary withdrawal of the PPI may be considered in some patientssee DRUG INTERACTIONS

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2018-10-03T07:46:14+00:00 2018 - 09 - 10|

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