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In vitrolamotrigine inhibited dihydrofolate reductasethe enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolateInhibition of this enzyme may interfere with the biosynthesis of nucleic acids and proteinsWhen oral daily doses of lamotrigine were given to pregnant rats during organogenesisfetalplacentaland maternal folate concentrations were reducedSignificantly reduced concentrations of folate are associated with teratogenesissee Use In Specific PopulationsFolate concentrations werealso reduced in malerats givenrepeated oral doses of lamotrigineReduced concentrations were partially returned to normal when supplemented with folinic acid.

Table 2Escalation Regimen for LAMICTAL in Patients Aged 2 to 12 Years With Epilepsy.

LAMICTAL is contraindicated in patients who have demonstrated hypersensitivitye.grashangioedemaacute urticariaextensive pruritusmucosal ulcerationto the drug or its ingredientssee BOXED WARNINGWARNINGS AND PRECAUTIONS

Your doctor will start you on low dose of lamotrigine and gradually increase your dosenot more than once every 1 to 2 weeksYou may be more likely to develop a serious rash if you take a higher starting dose or increase your dose faster than your doctor tells you that you shouldYour first doses of medication may be packaged in a starter kit that will clearly show you the right amount of medication to take each day during the first 5 weeks of your treatmentThis will help you to follow your doctor’s instructions as your dose is slowly increasedBe sure to take lamotrigine exactly as directedDo not take more or less of it or take it more often than prescribed by your doctor.

Inform patients who intend to breastfeed that LAMICTAL is present in breast milk and advise them to monitor their child for potential adverse effects of this drugDiscuss the benefits and risks of continuing breastfeeding.

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2018-10-13T13:15:20+00:00 2018 - 09 - 14|

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