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Read the Medication Guide if available from your pharmacist before you start taking hydroxyurea and each time you get a refillIf you have any questionsask your doctor or pharmacist.
Antineoplastic agents exert their benefits by killing rapidly growing cancer cellsUse of medications that stimulate cell growth is usually not recommended in patients who have been exposed to cytotoxic chemotherapy within 24 hoursSpecificallythe manufacturer of pegfilgrastimNeulastarecommends that pegfilgrastim should not be administered to patients who have been treated with cytotoxic chemotherapy within the prior 14 daysAlsochemotherapy should not be administered within 24 hours of pegfilgrastim.
Cutaneous vasculitic toxicitiesincluding vasculitic ulcerations and gangrenehave occurred in patients with myeloproliferative disorders during therapy with hydroxyureaThese vasculitic toxicities were reported most often in patients with a history ofor currently receivinginterferon therapyIf cutaneous vasculitic ulcers occurinstitute treatment and discontinue HYDREA.
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