Malhotra , kyle matschke , qiang wang , candace bramson , joanne salageanu , effects of ethanol on the pharmacokinetics of extended-release oxycodone with sequestered naltrexone alo-02 , clinical drug investigation , 2015 , 35 , 4, 267 crossref 3 anne brokj r , anne estrup olesen , mads kreilgaard , carina graversen , mikkel gram , lona louring christrup , albert dahan , asbj rn mohr drewes , objective markers of the analgesic response to morphine in experimental pain research, journal of pharmacological and toxicological methods , 2015 , 73 , 7 crossref 4 richard j.
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After opioid detoxificationpatients are likely to have reduced tolerance to opioidsAs the blockade of exogenous opioids provided by REVIA wanes and eventually dissipates completelypatients who have been treated with REVIA may respond to lower doses of opioids than previously usedjust as they would shortly after completing detoxification.
Patients with addictive disordersespecially opioid addictionare at risk for multiple numerous adverse events and abnormal laboratory findingsincluding liver function abnormalitiesData from both controlled and observational studies suggest that these abnormalitiesother than the dose-related hepatotoxicity described aboveare not related to the use of REVIA.
REVIA is indicated in the treatment of alcohol dependence and for the blockade of the effects of exogenously administered opioids.
In a situation requiring opioid analgesiathe amount of opioid required may be greater than usualand the resulting respiratory depression may be deeper and more prolonged.
REVIA has been shown to produce complete blockade of the euphoric effects of opioids in both volunteer and addict populationsWhen administered by means that enforce complianceit will produce an effective opioid blockadebut has not been shown to affect the use of cocaine or other non-opioid drugs of abuse.
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