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Hypersensitivity reactions to sertralineSee CONTRAINDICATIONSDisulfiram-alcohol reaction when ZOLOFT oral solution is taken with disulfiramSee CONTRAINDICATIONSQTc prolongation and ventricular arrhythmias when taken with pimozideSee CONTRAINDICATIONSCLINICAL PHARMACOLOGYSuicidal thoughts and behaviorsSee WARNINGS AND PRECAUTIONSSerotonin syndromeSee CONTRAINDICATIONSWARNINGS AND PRECAUTIONSDRUG INTERACTIONSIncreased risk of bleedingSee WARNINGS AND PRECAUTIONSActivation of mania/hypomaniaSee WARNINGS AND PRECAUTIONSDiscontinuation syndromeSee WARNINGS AND PRECAUTIONSSeizuresSee WARNINGS AND PRECAUTIONSAngle-closure glaucomaSee WARNINGS AND PRECAUTIONSHyponatremiaSee WARNINGS AND PRECAUTIONS
Inform patients not to take disulfiram when taking ZOLOFT oral solutionConcomitant use is contraindicated due the alcohol content of the oral solutionsee CONTRAINDICATIONS
This medication may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert.
PimozideTaking this drug with sertraline can cause serious heart problemsMonoamine oxidase inhibitorsMAOIssuch as isocarboxazidphenelzineand tranylcypromineTaking these drugs with sertraline increases your risk of serotonin syndromeYou must also wait 14 days between taking these drugs and taking sertralineLinezolidintravenous methylene blueTaking this drugs with sertraline increases your risk of serotonin syndrome.
Your family or other caregivers should also be alert to changes in your mood or symptomsYour doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
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study ocd-3 was a 12-week randomized, placebo controlled study with flexible dosing of zoloft in a range of 50 to 200 mg day; the mean dose for completers was 185 mg day.