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NSAIDs cause an increased risk of serious gastrointestinalGIadverse events including bleedingulcerationandperforation of the stomach or intestineswhich can be fatalThese events can occur at any time during use and without warning symptomsElderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for seriousGIeventssee WARNINGS AND PRECAUTIONS]
Because serious GI bleedinghepatotoxicityand renal injury can occur without warning symptoms or signsconsider monitoring patients on long-term NSAID treatment with a CBC and a chemistry profile periodically.
Inform patients about the signs and symptoms of serious skin reactionsand to discontinue the use of CELEBREX at the first appearance of skin rash or any other sign of hypersensitivityCELEBREX is contraindicated in patients with previous serious skin reactions to NSAIDssee CONTRAINDICATIONS
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in general, anti-inflammatory drugs that are taken once daily such as vioxx, bextra or feldene cause more fluid retention than drugs that must be taken several times a day celebrex, clinoril, motrin since the half life of the latter drugs allows the kidney some time away from the drug s side effect.