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Retinal vascular thrombosis has been reported in patients receiving estrogensDiscontinue medication pending examination if there is sudden partial or complete loss of visionor a sudden onset of proptosisdiplopia or migraineIf examination reveals papilledema or retinal vascular lesionsestrogens should be permanently discontinued.
Estrogens act through binding to nuclear receptors in estrogen-responsive tissuesTo datetwo estrogen receptors have been identifiedThese vary in proportion from tissue to tissue.
ESTRACE should not be used inwomen with undiagnosed abnormal genital bleedingknownsuspected or history of breast cancerknown or suspected estrogen-dependent neoplasiaactive deep vein thrombosispulmonary embolism or a history of these conditionsactive arterial thromboembolic diseasefor examplestrokemyocardial infarctionor a history of these conditionsknown anaphylactic reaction or angioedema to ESTRACEliver dysfunction or diseasethrombophilic disordersknown or suspected pregnancy.
4For treatment of advanced androgen-dependent carcinoma of the prostatefor palliation only.
NOTEThe number of doses per tube will vary with dosage requirements and patient handling.
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estrace is contraindicated in patients with the following conditions .