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Men treated with cyclophosphamide may develop oligospermia or azoospermia associated with increased gonadotropin but normal testosterone secretionSexual potency and libido are unimpaired in these patientsBoys treated with cyclophosphamide during prepubescence develop secondary sexual characteristics normallybut may have oligospermia or azoospermia and increased gonadotropin secretionSome degree of testicular atrophy may occurCyclophosphamide-induced azoospermia is reversible in some patientsthough the reversibility may not occur for several years after cessation of therapyMen temporarily rendered sterile by cyclophosphamide have subsequently fathered normal children.

Renal and Urinaryrenal failurerenal tubular disorderrenal impairmentnephropathy toxichemorrhagic cystitisbladder necrosiscystitis ulcerativebladder contracturehematurianephrogenic diabetes insipidusatypical urinary bladder epithelial cells.

Prevention of graft-versus-host disease after allogeneic hematopoietic stem cell transplant.

Use of cyclophosphamide during pregnancy may affect the fetusFetuses exposed to cyclophosphamide may be born with missing fingerstoes and a poorly-developed heartCyclophosphamide should not be administered during pregnancyCyclophosphamide is excreted in breast milk and could cause serious problems in the nursing infant.

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2018-10-22T07:31:17+00:00 2018 - 09 - 10|

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