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Maintenance dosage should range from 1 to 4 mg/kg bodyweight/day and must be adjusted according to clinical requirements and haematological tolerance.
Where possibleconcomitant administration of cytostatic drugsor drugs which may have a myelosuppressive effectsuch as penicillamineshould be avoidedThere are conflicting clinical reports of interactionsresulting in serious haematological abnormalitiesbetween Imuran and co-trimoxazole.
Chromosomal abnormalitieswhich disappear with timehave been demonstrated in lymphocytes from the offspring of patients treated with ImuranExcept in extremely rare casesno overt physical evidence of abnormality has been observed in the offspring of patients treated with ImuranAzathioprine and long-wave ultraviolet light have been shown to have a synergistic clastogenic effect in patients treated with azathioprine for a range of disorders.
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org i-am-a patient-caregive r treatments azathioprine-imuran information for patients and caregivers on azathioprine imuran such as usages, common dosages, drug interactions and possible side effects.