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Etodolac is a member of the pyranocarboxylic acid class of NSAIDsIn vitro data suggest that etodolac is not COX-2 selective in dogsHowever in vivo data are conflictingwith evidence suggesting that platelet thromboxane and gastric prostaglandin PGE 1 were not inhibited by etodolac in dogs at recommended therapeutic dosesThus it is difficult to definitively state whether or not etodolac is COX-1 sparing in vivoEtodolac is approved as an oral formulation for use in managing pain and inflammation associated with canine OAClinically it has been shown to improve rear limb function in dogs with chronic OAAdverse events are primarily seen in the GI tracthoweverkeratoconjunctivitis sicca has also been associated with etodolac administration.

When GI bleeding or ulceration occurs in patients receiving Etodolacthe treatment should be withdrawn.

The standard practices of gastric lavageactivated charcoal administration and general supportive therapy should be undertaken.

Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptomssee section 4.2and GI and cardiovascular risks below

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figure 2012-2017 etodolac methyl ester capacity production and growth rate.

2018-10-03T06:52:13+00:00 2018 - 09 - 14|

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