However, analysis of data from the clozaril national registry suggests that patients who have an initial episode of moderate leukopenia 3000 mm 3 wbc 2000 mm3 have up to a 12 -fold increased risk of having a subsequent episode of agranulocytosis when rechallenged compared to the full cohort of patients treated with clozaril clozapine .
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Patients who develop clozapine-induced myocarditis or cardiomyopathy should not be re-exposed to clozapinesee section 4.3 and 4.4
Data from two large observational studies showed that elderly people with dementia who are treated with antipsychotics are at a small increased risk of death compared with those who are not treatedThere are insufficient data to give a firm estimate of the precise magnitude of the risk and the cause of the increased risk is not known.
UsesFor the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatmentTo reduce the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorderwho are judged to be at chronic risk for re-experiencing suicidal behaviorbased on history and recent clinical state.
If you miss your doses for longer than a day or twoconsult your doctor for a new schedule to get back to the dose you were onsee Missed Dose sectionUse this medication regularly in order to get the most benefit from itTo help you rememberuse it at the same time(seach day.
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