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After a favorable response is notedthe proper maintenance dosage should be determined by decreasing the initial drug dosage in small increments at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reachedIt should be kept in mind that constant monitoring is needed in regard to drug dosageIncluded in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease processthe patient’s individual drug responsivenessand the effect of patient exposure to stressful situations not directly related to the disease entity under treatmentin this latter situation it may be necessary to increase the dosage of prednisoloneprednisoloneprednisoloneprednisolone tabletstabletstabletsfor a period of time consistent with the patient’s conditionIf after long-term therapy the drug is to be stoppedit is recommended that it be withdrawn gradually rather than abruptly.

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mutual inhibition of metabolism occurs with concurrent use of cyclosporin and methylprednisolone; therefore, it is possible that adverse events associated with the individual use of either drug may be more apt to occur.

2018-10-13T13:01:55+00:00 2018 - 09 - 15|

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