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The action of DEPO-MEDROL Sterile Aqueous Suspension injected intrasynovially appears to be well localized since significant metabolic effects characteristic of systemic administration of adrenal steroids have not been observedIn a few instances mild and transient improvement of structures other than those injected have been reportedNo other systemic effects have been notedHoweverit is possible that mild systemic effects may occur following intrasynovial administrationand this possibility is greater the larger the number of structures injected and the higher the total dose employed.

Therapeutic Good’s AdministrationTGAPharmaceutical Benefits SchemePBSGuildLink DrugBank.

Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystociafetal deathretained placenta and metritis.

With therapeutically equivalent dosesthe likelihood of occurrence of troublesome side effects is less with methylprednisolone than with prednisolonemoreoverside effects actually have been conspicuously absent during clinical trials with MEDROL Tablets in dogs and catsHowevermethylprednisolone is similar to prednisolone in regard to kinds of side effects and metabolic alterations to be anticipated when treatment is intensive or prolongedIn animal patients with diabetes mellitususe of methylprednisolone may be associated with an increase in the insulin requirementNegative nitrogen balance may occurparticularly in animals that require protracted maintenance therapymeasures to counteract persistent nitrogen loss include a high protein intake and the administration when indicatedof a suitable anabolic agentExcessive loss of potassiumlike excessive retention of sodiumis not likely to be induced by effective maintenance doses of MEDROLHoweverthese effects should be kept in mind and the usual regulatory measures employed as indicatedEcchymotic manifestationswhile not noted during the clinical evaluation in dogs and catsmay occurIf such reactions do occur and are seriousreduction in dosage or discontinuance of methylprednisolone therapy may be indicatedConcurrent use of daily oral supplements of ascorbic acid may be of value in helping to control ecchymotic tendencies.

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depo-medrol injection is also used concomitantly with other medications for palliative effect in patients suffering from leukaemia, lymphoma, multiple sclerosis, tuberculous meningitis etc.

2018-10-13T13:10:58+00:00 2018 - 09 - 14|

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