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Drugs That Interfere With HemostasisNSAIDsAspirinWarfarinetcSerotonin release by platelets plays an important role in hemostasisEpidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate the risk of bleedingAltered anticoagulant effectsincluding increased bleedinghave been reported when SSRIs and SNRIs are coadministered with warfarinPatients receiving warfarin therapy should be carefully monitored when Celexa is initiated or discontinued.

If concomitant use of Celexa with other serotonergic drugs includingtriptanstricyclic antidepressantsfentanyllithiumtramadolbuspironeamphetaminestryptophan and StJohn’s Wort is clinically warrantedpatients should be made aware of a potential increased risk for serotonin syndrome particularly during treatment initiation and dose increases.

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2018-10-03T08:11:05+00:00 2018 - 09 - 10|

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