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Organic causes of obesitye.ghypothyroidismshould be excluded before prescribing XENICAL.
This list is not completeOther drugs may interact with orlistatincluding prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guide.
Data from a XENICAL and cyclosporine drug interaction study indicate a reduction in cyclosporine plasma levels when XENICAL was coadministered with cyclosporineThereforeXENICAL and cyclosporine should not be simultaneously coadministeredTo reduce the chance of a drug-drug interactioncyclosporine should be taken at least 3 hours before or after XENICAL in patients taking both drugsIn additionin those patients whose cyclosporine levels are being measuredmore frequent monitoring should be considered.
Orlistat had no detectable mutagenic or genotoxic activity as determined by the Ames testa mammalian forward mutation assayV79/HPRTan in vitro clastogenesis assay in peripheral human lymphocytesan unscheduled DNA synthesis assayUDSin rat hepatocytes in cultureand an in vivo mouse micronucleus test.
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