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In animal modls, atovastatin lows plasma cholstol and lipopotin lvls by inhibiting HMG-CoA ductas and cholstol synthsis in th liv and by incasing th numb hpatic LDL cptos on th cll suac tnhanc uptak and catabolism LDL; atovastatin alsducs LDL poduction and th numb LDL paticls.

Clinical and pathologic studis show that lvatd plasma lvls total cholstol (total-C), LDL-cholstol (LDL-C) and apolipopotin B (apB) pomot human athosclosis and a isk actos dvloping cadiovascula disas, whil incasd lvls HDL-cholstol (HDL-C) a associatd with a dcasd cadiovascula isk. Lik LDL, cholstol-nichd TG-ich lipopotins, including VLDL, IDL and mnants, can alspomot athosclosis. lvatd plasma TGs a quntly ound in a tiad with low HDL-C lvls and small LDL paticls, as wll as in association with non-lipid mtabolic isk actos coonay hat disas (CHD). As such, total plasma TG has not consistntly bn shown tb an indpndnt isk actCHD. uthmo, th indpndnt ct aising HDL lowing TG on th isk coonay and cadiovascula mobidity and motality has not bn dtmind.

Niacin: Th isk skltal muscl cts may b nhancd whn atovastatin is usd in combination with niacin; a duction in ATOLIP CV dosag should b considd in this stting.

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atorlip-f fenofibrate tablets are indicated as adjunctive therapy to diet to reduce elevated low-density lipoprotein cholesterol ldl-c , total cholesterol total-c , triglycerides and apolipoprotein b apo b , and to increase high-density lipoprotein cholesterol hdl-c in adult patients with primary hypercholesterolemia or mixed dyslipidemia.

2018-10-03T08:18:22+00:00 2018 - 09 - 10|

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